Pleural fluid adenosine deaminase detection for the diagnosis of pleural tuberculosis*
نویسندگان
چکیده
* Study carried out at and sponsored by Gama Filho University. Jointly sponsored by FAPERJ E-26/170.647/2001. Correspondence to: Anete Trajman. Departamento de Medicina. Universidade Gama Filho. Rua Manoel Vitorino 553, Piedade, CEP 20748-900 – Rio de Janeiro, RJ. Submitted: 4 March 2004. Accepted, after review: 5 September 2004. Background: The diagnosis of pleural tuberculosis continues to be a challenge due to the low sensitivity of traditional diagnostic methods. Histopathological examination of pleural tissue is the most accurate method, with a sensitivity of up to 80%. Determination of adenosine deaminase levels is a recently introduced method, although its usefulness in the diagnosis of pleural tuberculosis in Brazil has yet to be well elucidated.
منابع مشابه
بررسی ارزش تشخیصی اندازهگیری آنزیم آدنوزین دآمیناز در مایع پلور، برای افتراق موارد بدخیمی و سل در مقایسه با بیوپسی پلور
Background & Aim: Pleural effusion is seen in the background of many diseases, two major groups of which are tuberculosis and malignancies. At present pleural biopsy helps us differentiate these two causes from each other, but it is not only an invasive method but also an expensive one. For this reason, investigators are in search of simple and less invasive methods to diagnose the cause of...
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Traditionally, Mycobacterium tuberculosis or granulomas have to be evidenced in the pleural cavity in order to establish a diagnosis of tuberculous pleuritis. In recent years, adenosine deaminase has aided tremendously in the diagnosis of tuberculous pleural effusion, often obviating the need for microbiologic or histologic verification of the diagnosis. However, the fact that the sensitivity o...
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Adenosine deaminase (ADA) can aid in the diagnosis of tuberculous pleural effusions, but false-positive findings from lymphocytic effusions have been reported. The purpose of this study is to assess the ADA levels in nontuberculous lymphocytic pleural effusions (lymphocyte count > 50%) of different aetiologies. Altogether, 410 nontuberculous lymphocytic pleural fluid samples were consecutively ...
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Aim: To determine the sensitivity and specificity of pleural fluid ADA for the diagnosis of tuberculous pleural effusion taking the cut off value of ADA as ≥ 40 mg/dl. Methods: It was a prospective, analytical study comprised of 220 patients having pleural effusion. Sputum smear examination and sputum culture for mycobacterium tuberculosis, pleural fluid examination for protein, glucose, cell c...
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